Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, Polynucleotide Kinase

Mammalian polynucleotide kinase (mPNK) is a critical DNA repair enzyme whose 5′-kinase and 3′-phoshatase activities function with poorly understood but striking specificity to restore 5′-phosphate/3′-hydroxyl termini at sites of DNA damage. Here we integrated site-directed mutagenesis and small-angl...

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Bibliographische Detailangaben
Hauptverfasser: Bernstein, N. K., Hammel, M., Mani, R. S., Weinfeld, M., Pelikan, M., Tainer, J. A., Glover, J. N. M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2009
Schlagworte:
Nucleic Acid Enzymes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764422/
https://ncbi.nlm.nih.gov/pubmed/19671525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp597
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