Structural and functional characterization of the PNKP–XRCC4–LigIV DNA repair complex

Non-homologous end joining (NHEJ) repairs DNA double strand breaks in non-cycling eukaryotic cells. NHEJ relies on polynucleotide kinase/phosphatase (PNKP), which generates 5΄-phosphate/3΄-hydroxyl DNA termini that are critical for ligation by the NHEJ DNA ligase, LigIV. PNKP and LigIV require the N...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Aceytuno, R. Daniel, Piett, Cortt G., Havali-Shahriari, Zahra, Edwards, Ross A., Rey, Martial, Ye, Ruiqiong, Javed, Fatima, Fang, Shujuan, Mani, Rajam, Weinfeld, Michael, Hammel, Michal, Tainer, John A., Schriemer, David C., Lees-Miller, Susan P., Glover, J.N. Mark
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Structural Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5449630/
https://ncbi.nlm.nih.gov/pubmed/28453785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx275
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