XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair

The XRCC4-like factor (XLF)-XRCC4 complex is essential for nonhomologous end joining, the major repair pathway for DNA double strand breaks in human cells. Yet, how XLF binds XRCC4 and impacts nonhomologous end joining functions has been enigmatic. Here, we report the XLF-XRCC4 complex crystal struc...

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Detalhes bibliográficos
Main Authors: Hammel, Michal, Rey, Martial, Yu, Yaping, Mani, Rajam S., Classen, Scott, Liu, Mona, Pique, Michael E., Fang, Shujuan, Mahaney, Brandi L., Weinfeld, Michael, Schriemer, David C., Lees-Miller, Susan P., Tainer, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173232/
https://ncbi.nlm.nih.gov/pubmed/21775435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.272641
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