XRCC4's interaction with XLF is required for coding (but not signal) end joining

XRCC4 and XLF are structurally related proteins important for DNA Ligase IV function. XRCC4 forms a tight complex with DNA Ligase IV while XLF interacts directly with XRCC4. Both XRCC4 and XLF form homodimers that can polymerize as heterotypic filaments independently of DNA Ligase IV. Emerging struc...

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Detalhes bibliográficos
Main Authors: Roy, Sunetra, Andres, Sara N., Vergnes, Alexandra, Neal, Jessica A., Xu, Yao, Yu, Yaping, Lees-Miller, Susan P., Junop, Murray, Modesti, Mauro, Meek, Katheryn
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287172/
https://ncbi.nlm.nih.gov/pubmed/22228831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1315
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