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XRCC4's interaction with XLF is required for coding (but not signal) end joining
XRCC4 and XLF are structurally related proteins important for DNA Ligase IV function. XRCC4 forms a tight complex with DNA Ligase IV while XLF interacts directly with XRCC4. Both XRCC4 and XLF form homodimers that can polymerize as heterotypic filaments independently of DNA Ligase IV. Emerging struc...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3287172/ https://ncbi.nlm.nih.gov/pubmed/22228831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1315 |
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