A human XRCC4–XLF complex bridges DNA

DNA double-strand breaks pose a significant threat to cell survival and must be repaired. In higher eukaryotes, such damage is repaired efficiently by non-homologous end joining (NHEJ). Within this pathway, XRCC4 and XLF fulfill key roles required for end joining. Using DNA-binding and -bridging ass...

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Autores principales: Andres, Sara N., Vergnes, Alexandra, Ristic, Dejan, Wyman, Claire, Modesti, Mauro, Junop, Murray
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2012
Materias:
Structural Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287209/
https://ncbi.nlm.nih.gov/pubmed/22287571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks022
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