XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair

The XRCC4-like factor (XLF)-XRCC4 complex is essential for nonhomologous end joining, the major repair pathway for DNA double strand breaks in human cells. Yet, how XLF binds XRCC4 and impacts nonhomologous end joining functions has been enigmatic. Here, we report the XLF-XRCC4 complex crystal struc...

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Bibliographic Details
Main Authors: Hammel, Michal, Rey, Martial, Yu, Yaping, Mani, Rajam S., Classen, Scott, Liu, Mona, Pique, Michael E., Fang, Shujuan, Mahaney, Brandi L., Weinfeld, Michael, Schriemer, David C., Lees-Miller, Susan P., Tainer, John A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173232/
https://ncbi.nlm.nih.gov/pubmed/21775435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.272641
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