XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair

DNA double strand breaks (DSBs), induced by ionizing radiation (IR) and endogenous stress including replication failure, are the most cytotoxic form of DNA damage. In human cells, most IR-induced DSBs are repaired by the non-homologous end joining (NHEJ) pathway. One of the most critical steps in NH...

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Autores principales: Mahaney, Brandi L., Hammel, Michal, Meek, Katheryn, Tainer, John A., Lees-Miller, Susan P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725335/
https://ncbi.nlm.nih.gov/pubmed/23442139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1139/bcb-2012-0058
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