Domain analysis of PNKP–XRCC1 interactions: Influence of genetic variants of XRCC1

Polynucleotide kinase/phosphatase (PNKP) and X-ray repair cross-complementing 1 (XRCC1) are key proteins in the single-strand DNA break repair pathway. Phosphorylated XRCC1 stimulates PNKP by binding to its forkhead-associated (FHA) domain, whereas nonphosphorylated XRCC1 stimulates PNKP by interact...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Mani, Rajam S., Mermershtain, Inbal, Abdou, Ismail, Fanta, Mesfin, Hendzel, Michael J., Glover, J. N. Mark, Weinfeld, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333889/
https://ncbi.nlm.nih.gov/pubmed/30446622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004262
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