Independent mechanisms of stimulation of polynucleotide kinase/phosphatase by phosphorylated and non-phosphorylated XRCC1

XRCC1 plays a central role in mammalian single-strand break repair. Although it has no enzymatic activity of its own, it stimulates the activities of polynucleotide kinase/phosphatase (PNKP), and this function is enhanced by protein kinase CK2 mediated phosphorylation of XRCC1. We have previously sh...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lu, Meiling, Mani, Rajam S., Karimi-Busheri, Feridoun, Fanta, Mesfin, Wang, Hailin, Litchfeld, David W., Weinfeld, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2010
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811000/
https://ncbi.nlm.nih.gov/pubmed/19910369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1023
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