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Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair
Mutations in mitochondrial DNA (mtDNA) are implicated in a broad range of human diseases and in aging. Compared to nuclear DNA, mtDNA is more highly exposed to oxidative damage due to its proximity to the respiratory chain and the lack of protection afforded by chromatin-associated proteins. While r...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3333865/ https://ncbi.nlm.nih.gov/pubmed/22210862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1245 |
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