DIMP53‐1: a novel small‐molecule dual inhibitor of p53–MDM2/X interactions with multifunctional p53‐dependent anticancer properties

The transcription factor p53 plays a crucial role in cancer development and dissemination, and thus, p53‐targeted therapies are among the most encouraging anticancer strategies. In human cancers with wild‐type (wt) p53, its inactivation by interaction with murine double minute (MDM)2 and MDMX is a c...

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Dettagli Bibliografici
Pubblicato in:Mol Oncol
Autori principali: Soares, Joana, Espadinha, Margarida, Raimundo, Liliana, Ramos, Helena, Gomes, Ana Sara, Gomes, Sara, Loureiro, Joana B., Inga, Alberto, Reis, Flávio, Gomes, Célia, Santos, Maria M. M., Saraiva, Lucília
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467495/
https://ncbi.nlm.nih.gov/pubmed/28296148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12051
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