SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma

Half of human cancers harbor TP53 mutations that render p53 inactive as a tumor suppressor. In these cancers, reactivation of mutant p53 (mutp53) through restoration of wild-type-like function constitutes a valuable anticancer therapeutic strategy. In order to search for mutp53 reactivators, a small...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancers (Basel)
Egile Nagusiak: Gomes, Sara, Bosco, Bartolomeo, Loureiro, Joana B., Ramos, Helena, Raimundo, Liliana, Soares, Joana, Nazareth, Nair, Barcherini, Valentina, Domingues, Lucília, Oliveira, Carla, Bisio, Alessandra, Piazza, Silvano, Bauer, Matthias R., Brás, João P., Almeida, Maria Inês, Gomes, Célia, Reis, Flávio, Fersht, Alan R., Inga, Alberto, Santos, Maria M. M., Saraiva, Lucília
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721528/
https://ncbi.nlm.nih.gov/pubmed/31405179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11081151
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