Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Dissemination and Therapeutic Resistance

SIMPLE SUMMARY: Melanoma is a highly metastatic and therapy-resistant cancer and is therefore associated with low survival rates of patients. In melanoma, the inactivation of the wild-type form of the p53 tumour suppressor protein is a frequent event, mainly through interactions with MDM2 and MDMX....

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Loureiro, Joana B., Raimundo, Liliana, Calheiros, Juliana, Carvalho, Carla, Barcherini, Valentina, Lima, Nuno R., Gomes, Célia, Almeida, Maria Inês, Alves, Marco G., Costa, José Luís, Santos, Maria M. M., Saraiva, Lucília
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8037490/
https://ncbi.nlm.nih.gov/pubmed/33916029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13071648
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