Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule

Restoration of the p53 pathway, namely by reactivation of mutant (mut) p53, represents a valuable anticancer strategy. Herein, we report the identification of the enantiopure tryptophanol-derived oxazoloisoindolinone SLMP53-1 as a novel reactivator of wild-type (wt) and mut p53, using a yeast-based...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Soares, Joana, Raimundo, Liliana, Pereira, Nuno A.L., Monteiro, Ângelo, Gomes, Sara, Bessa, Cláudia, Pereira, Clara, Queiroz, Glória, Bisio, Alessandra, Fernandes, João, Gomes, Célia, Reis, Flávio, Gonçalves, Jorge, Inga, Alberto, Santos, Maria M.M., Saraiva, Lucília
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2015
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826208/
https://ncbi.nlm.nih.gov/pubmed/26735173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6775
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