DIMP53‐1: a novel small‐molecule dual inhibitor of p53–MDM2/X interactions with multifunctional p53‐dependent anticancer properties

The transcription factor p53 plays a crucial role in cancer development and dissemination, and thus, p53‐targeted therapies are among the most encouraging anticancer strategies. In human cancers with wild‐type (wt) p53, its inactivation by interaction with murine double minute (MDM)2 and MDMX is a c...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Soares, Joana, Espadinha, Margarida, Raimundo, Liliana, Ramos, Helena, Gomes, Ana Sara, Gomes, Sara, Loureiro, Joana B., Inga, Alberto, Reis, Flávio, Gomes, Célia, Santos, Maria M. M., Saraiva, Lucília
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467495/
https://ncbi.nlm.nih.gov/pubmed/28296148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12051
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