Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c

Mutations in CHCHD2 have been identified in some Parkinson's disease (PD) cases. To understand the physiological and pathological roles of CHCHD2, we manipulated the expression of CHCHD2 in Drosophila and mammalian cells. The loss of CHCHD2 in Drosophila causes abnormal matrix structures and im...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Meng, Hongrui, Yamashita, Chikara, Shiba-Fukushima, Kahori, Inoshita, Tsuyoshi, Funayama, Manabu, Sato, Shigeto, Hatta, Tomohisa, Natsume, Tohru, Umitsu, Masataka, Takagi, Junichi, Imai, Yuzuru, Hattori, Nobutaka
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467237/
https://ncbi.nlm.nih.gov/pubmed/28589937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15500
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