Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c

Mutations in CHCHD2 have been identified in some Parkinson's disease (PD) cases. To understand the physiological and pathological roles of CHCHD2, we manipulated the expression of CHCHD2 in Drosophila and mammalian cells. The loss of CHCHD2 in Drosophila causes abnormal matrix structures and im...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Nat Commun
Autori principali: Meng, Hongrui, Yamashita, Chikara, Shiba-Fukushima, Kahori, Inoshita, Tsuyoshi, Funayama, Manabu, Sato, Shigeto, Hatta, Tomohisa, Natsume, Tohru, Umitsu, Masataka, Takagi, Junichi, Imai, Yuzuru, Hattori, Nobutaka
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467237/
https://ncbi.nlm.nih.gov/pubmed/28589937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15500
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi