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Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents
Culture-based blood–brain barrier (BBB) models are crucial tools to enable rapid screening of brain-penetrating drugs. However, reproducibility of in vitro barrier properties and permeability remain as major challenges. Here, we report that self-assembling multicellular BBB spheroids display reprodu...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5467173/ https://ncbi.nlm.nih.gov/pubmed/28585535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15623 |
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