Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

Culture-based blood–brain barrier (BBB) models are crucial tools to enable rapid screening of brain-penetrating drugs. However, reproducibility of in vitro barrier properties and permeability remain as major challenges. Here, we report that self-assembling multicellular BBB spheroids display reprodu...

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Udgivet i:Nat Commun
Main Authors: Cho, Choi-Fong, Wolfe, Justin M., Fadzen, Colin M., Calligaris, David, Hornburg, Kalvis, Chiocca, E. Antonio, Agar, Nathalie Y. R., Pentelute, Bradley L., Lawler, Sean E.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467173/
https://ncbi.nlm.nih.gov/pubmed/28585535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15623
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