Substituted cysteine accessibility method (SCAM) analysis of the transport domain of human concentrative nucleoside transporter 3 (hCNT3) and other family members reveals features of structural and functional importance

The human SLC28 family of concentrative nucleoside transporter (CNT) proteins has three members: hCNT1, hCNT2, and hCNT3. Na(+)-coupled hCNT1 and hCNT2 transport pyrimidine and purine nucleosides, respectively, whereas hCNT3 transports both pyrimidine and purine nucleosides utilizing Na(+) and/or H(...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Mulinta, Ras, Yao, Sylvia Y. M., Ng, Amy M. L., Cass, Carol E., Young, James D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Membrane Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465479/
https://ncbi.nlm.nih.gov/pubmed/28385889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.743997
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