Conserved Glutamate Residues Glu-343 and Glu-519 Provide Mechanistic Insights into Cation/Nucleoside Cotransport by Human Concentrative Nucleoside Transporter hCNT3

Human concentrative nucleoside transporter 3 (hCNT3) utilizes electrochemical gradients of both Na(+) and H(+) to accumulate pyrimidine and purine nucleosides within cells. We have employed radioisotope flux and electrophysiological techniques in combination with site-directed mutagenesis and hetero...

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Détails bibliographiques
Auteurs principaux: Slugoski, Melissa D., Smith, Kyla M., Ng, Amy M. L., Yao, Sylvia Y. M., Karpinski, Edward, Cass, Carol E., Baldwin, Stephen A., Young, James D.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
Membrane Transport, Structure, Function, and Biogenesis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719363/
https://ncbi.nlm.nih.gov/pubmed/19380587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.009613
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