A Proton-mediated Conformational Shift Identifies a Mobile Pore-lining Cysteine Residue (Cys-561) in Human Concentrative Nucleoside Transporter 3

The concentrative nucleoside transporter (CNT) protein family in humans is represented by three members, hCNT1, hCNT2, and hCNT3. Belonging to a CNT subfamily phylogenetically distinct from hCNT1/2, hCNT3 mediates transport of a broad range of purine and pyrimidine nucleosides and nucleoside drugs,...

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Main Authors: Slugoski, Melissa D., Ng, Amy M. L., Yao, Sylvia Y. M., Smith, Kyla M., Lin, Colin C., Zhang, Jing, Karpinski, Edward, Cass, Carol E., Baldwin, Stephen A., Young, James D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2417190/
https://ncbi.nlm.nih.gov/pubmed/18199742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710433200
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