Pore conformations and gating mechanism of a Cys-loop receptor

Neurons regulate the propagation of chemoelectric signals throughout the nervous system by opening and closing ion channels, a process known as gating. Here, histidine-based metal-binding sites were engineered along the intrinsic pore of a chimeric Cys-loop receptor to probe state-dependent Zn(2+)-c...

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Main Authors: Paas, Yoav, Gibor, Gilad, Grailhe, Regis, Savatier-Duclert, Nathalie, Dufresne, Virginie, Sunesen, Morten, de Carvalho, Lia Prado, Changeux, Jean-Pierre, Attali, Bernard
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276086/
https://ncbi.nlm.nih.gov/pubmed/16247006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507599102
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