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Pore conformations and gating mechanism of a Cys-loop receptor
Neurons regulate the propagation of chemoelectric signals throughout the nervous system by opening and closing ion channels, a process known as gating. Here, histidine-based metal-binding sites were engineered along the intrinsic pore of a chimeric Cys-loop receptor to probe state-dependent Zn(2+)-c...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1276086/ https://ncbi.nlm.nih.gov/pubmed/16247006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507599102 |
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