Megalin Blockade with Cilastatin Suppresses Drug-Induced Nephrotoxicity

Nephrotoxicity induced by antimicrobial or anticancer drugs is a serious clinical problem. Megalin, an endocytic receptor expressed at the apical membranes of proximal tubules, mediates the nephrotoxicity of aminoglycosides and colistin, key antimicrobials for multidrug-resistant organisms. The mech...

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Udgivet i:J Am Soc Nephrol
Main Authors: Hori, Yoshihisa, Aoki, Nobumasa, Kuwahara, Shoji, Hosojima, Michihiro, Kaseda, Ryohei, Goto, Sawako, Iida, Tomomichi, De, Shankhajit, Kabasawa, Hideyuki, Kaneko, Reika, Aoki, Hiroyuki, Tanabe, Yoshinari, Kagamu, Hiroshi, Narita, Ichiei, Kikuchi, Toshiaki, Saito, Akihiko
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2017
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461786/
https://ncbi.nlm.nih.gov/pubmed/28052987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016060606
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