Combination therapy of cisplatin with cilastatin enables an increased dose of cisplatin, enhancing its antitumor effect by suppression of nephrotoxicity

Cisplatin, one of the most active anticancer agents, is widely used in standard chemotherapy for various cancers. Cisplatin is more poorly tolerated than other chemotherapeutic drugs, and the main dose-limiting toxicity of cisplatin is its nephrotoxicity, which is dose-dependent. Although less toxic...

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Publicado no:Sci Rep
Main Authors: Arita, Masashi, Watanabe, Satoshi, Aoki, Nobumasa, Kuwahara, Shoji, Suzuki, Ryo, Goto, Sawako, Abe, Yuko, Takahashi, Miho, Sato, Miyuki, Hokari, Satoshi, Ohtsubo, Aya, Shoji, Satoshi, Nozaki, Koichiro, Ichikawa, Kosuke, Kondo, Rie, Hayashi, Masachika, Ohshima, Yasuyoshi, Kabasawa, Hideyuki, Hosojima, Michihiro, Koya, Toshiyuki, Saito, Akihiko, Kikuchi, Toshiaki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7804437/
https://ncbi.nlm.nih.gov/pubmed/33437029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80853-6
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