Combination therapy of cisplatin with cilastatin enables an increased dose of cisplatin, enhancing its antitumor effect by suppression of nephrotoxicity

Cisplatin, one of the most active anticancer agents, is widely used in standard chemotherapy for various cancers. Cisplatin is more poorly tolerated than other chemotherapeutic drugs, and the main dose-limiting toxicity of cisplatin is its nephrotoxicity, which is dose-dependent. Although less toxic...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Arita, Masashi, Watanabe, Satoshi, Aoki, Nobumasa, Kuwahara, Shoji, Suzuki, Ryo, Goto, Sawako, Abe, Yuko, Takahashi, Miho, Sato, Miyuki, Hokari, Satoshi, Ohtsubo, Aya, Shoji, Satoshi, Nozaki, Koichiro, Ichikawa, Kosuke, Kondo, Rie, Hayashi, Masachika, Ohshima, Yasuyoshi, Kabasawa, Hideyuki, Hosojima, Michihiro, Koya, Toshiyuki, Saito, Akihiko, Kikuchi, Toshiaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7804437/
https://ncbi.nlm.nih.gov/pubmed/33437029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80853-6
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