Correlation of prechemotherapy urinary megalin ectodomain (A-megalin) levels with the development of cisplatin-induced nephrotoxicity: a prospective observational study

BACKGROUND: Cisplatin is a potent chemotherapeutic agent used to treat a variety of solid tumors. One of the major side effects of cisplatin is dose-limiting nephrotoxicity. We recently demonstrated that the renal uptake of cisplatin and resultant cisplatin-induced nephrotoxicity are mediated in par...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Shoji, Satoshi, Hosojima, Michihiro, Kabasawa, Hideyuki, Kondo, Rie, Miura, Satoru, Watanabe, Satoshi, Aoki, Nobumasa, Kaseda, Ryohei, Kuwahara, Shoji, Tanabe, Naohito, Hirayama, Yoshiaki, Narita, Ichiei, Kikuchi, Toshiaki, Kagamu, Hiroshi, Saito, Akihiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889728/
https://ncbi.nlm.nih.gov/pubmed/31791266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-6398-2
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