Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses

Certain RGD-binding integrins are required for cell adhesion, migration, and proliferation and are overexpressed in most tumors, making them attractive therapeutic targets. However, multiple integrin antagonist drug candidates have failed to show efficacy in cancer clinical trials. In this work, we...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Kwan, Byron H., Zhu, Eric F., Tzeng, Alice, Sugito, Harun R., Eltahir, Ahmed A., Ma, Botong, Delaney, Mary K., Murphy, Patrick A., Kauke, Monique J., Angelini, Alessandro, Momin, Noor, Mehta, Naveen K., Maragh, Alecia M., Hynes, Richard O., Dranoff, Glenn, Cochran, Jennifer R., Wittrup, K. Dane
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460993/
https://ncbi.nlm.nih.gov/pubmed/28473400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160831
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