Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses

Certain RGD-binding integrins are required for cell adhesion, migration, and proliferation and are overexpressed in most tumors, making them attractive therapeutic targets. However, multiple integrin antagonist drug candidates have failed to show efficacy in cancer clinical trials. In this work, we...

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Vydáno v:J Exp Med
Hlavní autoři: Kwan, Byron H., Zhu, Eric F., Tzeng, Alice, Sugito, Harun R., Eltahir, Ahmed A., Ma, Botong, Delaney, Mary K., Murphy, Patrick A., Kauke, Monique J., Angelini, Alessandro, Momin, Noor, Mehta, Naveen K., Maragh, Alecia M., Hynes, Richard O., Dranoff, Glenn, Cochran, Jennifer R., Wittrup, K. Dane
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2017
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460993/
https://ncbi.nlm.nih.gov/pubmed/28473400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160831
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