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Localized immunotherapy via liposome-anchored anti-CD137 + IL-2 prevents lethal toxicity and elicits local and systemic anti-tumor immunity

Immunostimulatory agonists such as anti-CD137 and interleukin-2 (IL-2) have elicited potent anti-tumor immune responses in preclinical studies, but their clinical use is limited by inflammatory toxicities that result upon systemic administration. We hypothesized that by rigorously restricting the bi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kwong, Brandon, Gai, S. Annie, Elkhader, Jamal, Wittrup, K. Dane, Irvine, Darrell J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594475/
https://ncbi.nlm.nih.gov/pubmed/23436794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-3343
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