Llwytho...

Localized immunotherapy via liposome-anchored anti-CD137 + IL-2 prevents lethal toxicity and elicits local and systemic anti-tumor immunity

Immunostimulatory agonists such as anti-CD137 and interleukin-2 (IL-2) have elicited potent anti-tumor immune responses in preclinical studies, but their clinical use is limited by inflammatory toxicities that result upon systemic administration. We hypothesized that by rigorously restricting the bi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kwong, Brandon, Gai, S. Annie, Elkhader, Jamal, Wittrup, K. Dane, Irvine, Darrell J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594475/
https://ncbi.nlm.nih.gov/pubmed/23436794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-3343
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