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Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis
Chemokine receptors typically have multiple ligands. Consequently, treatment with a blocking antibody against a single chemokine is expected to be insufficient for efficacy. Here we show single-chain antibodies can be engineered for broad crossreactivity toward multiple human and mouse proinflammato...
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| Veröffentlicht in: | Nat Commun |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5899157/ https://ncbi.nlm.nih.gov/pubmed/29654232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03687-x |
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