Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle

Temporally and spatially constrained Hedgehog (Hh) signaling regulates cyclic growth of hair follicle epithelium while constitutive Hh signaling drives the development of basal cell carcinomas (BCCs), the most common cancers in humans. Using mice engineered to conditionally express the Hh effector G...

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Detalhes bibliográficos
Main Authors: Hutchin, Mark E., Kariapper, Muhammed S.T., Grachtchouk, Marina, Wang, Aiqin, Wei, Lebing, Cummings, Donelle, Liu, Jianhong, Michael, L. Evan, Glick, Adam, Dlugosz, Andrzej A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2005
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC545881/
https://ncbi.nlm.nih.gov/pubmed/15625189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1258705
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