The magnitude of hedgehog signaling activity defines skin tumor phenotype

Gain-of-function mutations in SMO have been implicated in constitutive activation of the hedgehog signaling pathway in human basal cell carcinomas (BCCs). We used a truncated keratin 5 (ΔK5) promoter to assess the potential role of the human M2SMO mutant in BCC development in adult transgenic mice....

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Detaylı Bibliyografya
Asıl Yazarlar: Grachtchouk, Vladimir, Grachtchouk, Marina, Lowe, Lori, Johnson, Tim, Wei, Lebing, Wang, Aiqin, de Sauvage, Fred, Dlugosz, Andrzej A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2003
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC156767/
https://ncbi.nlm.nih.gov/pubmed/12773389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg271
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