Odontogenic Keratocysts Arise from Quiescent Epithelial Rests and Are Associated with Deregulated Hedgehog Signaling in Mice and Humans

Odontogenic keratocysts in humans are aggressive, noninflammatory jaw cysts that may harbor PTCH1 mutations, leading to constitutive activity of the embryonic Hedgehog (Hh) signaling pathway. We show here that epithelial expression of the Hh transcriptional effector Gli2 is sufficient for highly pen...

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Bibliografski detalji
Glavni autori: Grachtchouk, Marina, Liu, Jianhong, Wang, Aiqin, Wei, Lebing, Bichakjian, Christopher K., Garlick, Jonathan, Paulino, Augusto F., Giordano, Thomas, Dlugosz, Andrzej A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2006
Teme:
Regular Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698812/
https://ncbi.nlm.nih.gov/pubmed/16936257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.060054
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