Odontogenic Keratocysts Arise from Quiescent Epithelial Rests and Are Associated with Deregulated Hedgehog Signaling in Mice and Humans

Odontogenic keratocysts in humans are aggressive, noninflammatory jaw cysts that may harbor PTCH1 mutations, leading to constitutive activity of the embryonic Hedgehog (Hh) signaling pathway. We show here that epithelial expression of the Hh transcriptional effector Gli2 is sufficient for highly pen...

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Detalhes bibliográficos
Principais autores: Grachtchouk, Marina, Liu, Jianhong, Wang, Aiqin, Wei, Lebing, Bichakjian, Christopher K., Garlick, Jonathan, Paulino, Augusto F., Giordano, Thomas, Dlugosz, Andrzej A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698812/
https://ncbi.nlm.nih.gov/pubmed/16936257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.060054
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