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The magnitude of hedgehog signaling activity defines skin tumor phenotype
Gain-of-function mutations in SMO have been implicated in constitutive activation of the hedgehog signaling pathway in human basal cell carcinomas (BCCs). We used a truncated keratin 5 (ΔK5) promoter to assess the potential role of the human M2SMO mutant in BCC development in adult transgenic mice....
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC156767/ https://ncbi.nlm.nih.gov/pubmed/12773389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg271 |
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