Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle

Temporally and spatially constrained Hedgehog (Hh) signaling regulates cyclic growth of hair follicle epithelium while constitutive Hh signaling drives the development of basal cell carcinomas (BCCs), the most common cancers in humans. Using mice engineered to conditionally express the Hh effector G...

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Autors principals: Hutchin, Mark E., Kariapper, Muhammed S.T., Grachtchouk, Marina, Wang, Aiqin, Wei, Lebing, Cummings, Donelle, Liu, Jianhong, Michael, L. Evan, Glick, Adam, Dlugosz, Andrzej A.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2005
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC545881/
https://ncbi.nlm.nih.gov/pubmed/15625189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1258705
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