Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle

Temporally and spatially constrained Hedgehog (Hh) signaling regulates cyclic growth of hair follicle epithelium while constitutive Hh signaling drives the development of basal cell carcinomas (BCCs), the most common cancers in humans. Using mice engineered to conditionally express the Hh effector G...

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Autori principali: Hutchin, Mark E., Kariapper, Muhammed S.T., Grachtchouk, Marina, Wang, Aiqin, Wei, Lebing, Cummings, Donelle, Liu, Jianhong, Michael, L. Evan, Glick, Adam, Dlugosz, Andrzej A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2005
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC545881/
https://ncbi.nlm.nih.gov/pubmed/15625189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1258705
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