The Sonic Hedgehog-Induced Type 3 Deiodinase Facilitates Tumorigenesis of Basal Cell Carcinoma by Reducing Gli2 Inactivation

Thyroid hormone (TH) is an important regulator of growth, development, and metabolism. Most of the active TH T(3) is generated by peripheral TH metabolism mediated by the iodothyronine deiodinases. Type 3 deiodinase (D3) inactivates T(3) via specific deiodination reactions. It is an oncofetal protei...

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Détails bibliographiques
Publié dans:Endocrinology
Auteurs principaux: Luongo, Cristina, Ambrosio, Raffaele, Salzano, Salvatore, Dlugosz, Andrzej A., Missero, Caterina, Dentice, Monica
Format: Artigo
Langue:Inglês
Publié: Endocrine Society 2014
Sujets:
Cancer-Oncogenes
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393316/
https://ncbi.nlm.nih.gov/pubmed/24693967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-2108
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