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Trim32 suppresses cerebellar development and tumorigenesis by degrading Gli1/sonic hedgehog signaling
Sonic hedgehog (SHH) signaling is crucial for the maintenance of the physiological self-renewal of granule neuron progenitor cells (GNPs) during cerebellar development, and its dysregulation leads to oncogenesis. However, how SHH signaling is controlled during cerebellar development is poorly unders...
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| Pubblicato in: | Cell Death Differ |
|---|---|
| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7206143/ https://ncbi.nlm.nih.gov/pubmed/31527798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0415-5 |
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