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Sonic hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing Its Processing and Degradation

Gli2 and Gli3 are the primary transcription factors that mediate Sonic hedgehog (Shh) signals in the mouse. Gli3 mainly acts as a transcriptional repressor, because the majority of full-length Gli3 protein is proteolytically processed. Gli2 is mostly regarded as a transcriptional activator, even tho...

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Bibliografische gegevens
Hoofdauteurs: Pan, Yong, Bai, Chunyang Brian, Joyner, Alexandra L., Wang, Baolin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2006
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1447407/
https://ncbi.nlm.nih.gov/pubmed/16611981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.9.3365-3377.2006
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