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Increased proteolytic processing of full-length Gli2 transcription factor reduces the Hedgehog pathway activity in vivo
The proteolytic processing of Gli2 and Gli3 full-length transcription factors into repressors is a key step of the regulation in Hedgehog (Hh) signaling. The differential Gli2 and Gli3 processing is controlled by the processing determinant domain or PDD, but its significance is not clear. We generat...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3071291/ https://ncbi.nlm.nih.gov/pubmed/21337666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.22578 |
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