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Natural Product and Natural Product-Derived Gamma Secretase Modulators from Actaea Racemosa Extracts

Alzheimer’s disease is characterized by pathogenic oligomerization, aggregation, and deposition of amyloid beta peptide (Aβ), resulting in severe neuronal toxicity and associated cognitive dysfunction. In particular, increases in the absolute or relative level of the major long form of Aβ, Aβ42, are...

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Detalhes bibliográficos
Publicado no:Medicines (Basel)
Main Authors: Findeis, Mark A., Schroeder, Frank C., Creaser, Steffen P., McKee, Timothy D., Xia, Weiming
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5456218/
https://ncbi.nlm.nih.gov/pubmed/28930205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/medicines2030127
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