ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia

Additional sex combs-like (ASXL) proteins are mammalian homologues of additional sex combs (Asx), a regulator of trithorax and polycomb function in Drosophila. While there has been great interest in ASXL1 due to its frequent mutation in leukemia, little is known about its paralog ASXL2, which is fre...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nat Commun
Main Authors: Micol, Jean-Baptiste, Pastore, Alessandro, Inoue, Daichi, Duployez, Nicolas, Kim, Eunhee, Lee, Stanley Chun-Wei, Durham, Benjamin H., Chung, Young Rock, Cho, Hana, Zhang, Xiao Jing, Yoshimi, Akihide, Krivtsov, Andrei, Koche, Richard, Solary, Eric, Sinha, Amit, Preudhomme, Claude, Abdel-Wahab, Omar
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2017
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454368/
https://ncbi.nlm.nih.gov/pubmed/28516957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15429
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