SETBP1 Mutations Drive Leukemic Transformation in ASXL1-Mutated MDS

Mutations in ASXL1 are frequent in patients with myelodysplastic syndrome (MDS) and associated with adverse survival yet the molecular pathogenesis of ASXL1 mutations are not fully understood. Recently it has been found that deletion of Asxl1 or expression of C-terminal-truncating ASXL1 mutations (A...

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Vydáno v:Leukemia
Hlavní autoři: Inoue, Daichi, Kitaura, Jiro, Matsui, Hirotaka, Hou, Hsin-An, Chou, Wen-Chien, Nagamachi, Akiko, Kawabata, Kimihito Cojin, Togami, Katsuhiro, Nagase, Reina, Horikawa, Sayuri, Saika, Makoto, Micol, Jean-Baptiste, Hayashi, Yasutaka, Harada, Yuka, Harada, Hironori, Inaba, Toshiya, Tien, Hwei-Fang, Abdel-Wahab, Omar, Kitamura, Toshio
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501574/
https://ncbi.nlm.nih.gov/pubmed/25306901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.301
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