Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations

Recurrent mutations in the gene encoding additional sex combs-like 1 (ASXL1) are found in various hematologic malignancies and associated with poor prognosis. In particular, ASXL1 mutations are common in patients with hematologic malignancies associated with myelodysplasia, including myelodysplastic...

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Detalhes bibliográficos
Main Authors: Inoue, Daichi, Kitaura, Jiro, Togami, Katsuhiro, Nishimura, Koutarou, Enomoto, Yutaka, Uchida, Tomoyuki, Kagiyama, Yuki, Kawabata, Kimihito Cojin, Nakahara, Fumio, Izawa, Kumi, Oki, Toshihiko, Maehara, Akie, Isobe, Masamichi, Tsuchiya, Akiho, Harada, Yuka, Harada, Hironori, Ochiya, Takahiro, Aburatani, Hiroyuki, Kimura, Hiroshi, Thol, Felicitas, Heuser, Michael, Levine, Ross L., Abdel-Wahab, Omar, Kitamura, Toshio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3809801/
https://ncbi.nlm.nih.gov/pubmed/24216483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70739
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