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Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation
Additional sex combs like 1 (ASXL1) is frequently mutated in myeloid malignancies and clonal hematopoiesis of indeterminate potential (CHIP). Although loss of ASXL1 promotes hematopoietic transformation, there is growing evidence that ASXL1 mutations might confer an alteration of function. In this s...
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| Опубликовано в: : | J Exp Med |
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| Главные авторы: | , , , , , , , , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Rockefeller University Press
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5987913/ https://ncbi.nlm.nih.gov/pubmed/29643185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171151 |
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