Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation

Additional sex combs like 1 (ASXL1) is frequently mutated in myeloid malignancies and clonal hematopoiesis of indeterminate potential (CHIP). Although loss of ASXL1 promotes hematopoietic transformation, there is growing evidence that ASXL1 mutations might confer an alteration of function. In this s...

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Опубликовано в: :J Exp Med
Главные авторы: Nagase, Reina, Inoue, Daichi, Pastore, Alessandro, Fujino, Takeshi, Hou, Hsin-An, Yamasaki, Norimasa, Goyama, Susumu, Saika, Makoto, Kanai, Akinori, Sera, Yasuyuki, Horikawa, Sayuri, Ota, Yasunori, Asada, Shuhei, Hayashi, Yasutaka, Kawabata, Kimihito Cojin, Takeda, Reina, Tien, Hwei-Fang, Honda, Hiroaki, Abdel-Wahab, Omar, Kitamura, Toshio
Формат: Artigo
Язык:Inglês
Опубликовано: Rockefeller University Press 2018
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987913/
https://ncbi.nlm.nih.gov/pubmed/29643185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171151
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