Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation

Additional sex combs like 1 (ASXL1) is frequently mutated in myeloid malignancies and clonal hematopoiesis of indeterminate potential (CHIP). Although loss of ASXL1 promotes hematopoietic transformation, there is growing evidence that ASXL1 mutations might confer an alteration of function. In this s...

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Bibliografische gegevens
Gepubliceerd in:J Exp Med
Hoofdauteurs: Nagase, Reina, Inoue, Daichi, Pastore, Alessandro, Fujino, Takeshi, Hou, Hsin-An, Yamasaki, Norimasa, Goyama, Susumu, Saika, Makoto, Kanai, Akinori, Sera, Yasuyuki, Horikawa, Sayuri, Ota, Yasunori, Asada, Shuhei, Hayashi, Yasutaka, Kawabata, Kimihito Cojin, Takeda, Reina, Tien, Hwei-Fang, Honda, Hiroaki, Abdel-Wahab, Omar, Kitamura, Toshio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Rockefeller University Press 2018
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987913/
https://ncbi.nlm.nih.gov/pubmed/29643185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171151
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