Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation

Additional sex combs like 1 (ASXL1) is frequently mutated in myeloid malignancies and clonal hematopoiesis of indeterminate potential (CHIP). Although loss of ASXL1 promotes hematopoietic transformation, there is growing evidence that ASXL1 mutations might confer an alteration of function. In this s...

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Vydáno v:J Exp Med
Hlavní autoři: Nagase, Reina, Inoue, Daichi, Pastore, Alessandro, Fujino, Takeshi, Hou, Hsin-An, Yamasaki, Norimasa, Goyama, Susumu, Saika, Makoto, Kanai, Akinori, Sera, Yasuyuki, Horikawa, Sayuri, Ota, Yasunori, Asada, Shuhei, Hayashi, Yasutaka, Kawabata, Kimihito Cojin, Takeda, Reina, Tien, Hwei-Fang, Honda, Hiroaki, Abdel-Wahab, Omar, Kitamura, Toshio
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2018
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987913/
https://ncbi.nlm.nih.gov/pubmed/29643185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171151
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