Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations

Acute myeloid leukemia (AML) with t(8;21) (q22;q22) is considered to have favorable risk; however, nearly half of t(8;21) patients are not cured, and recent studies have highlighted remarkable genetic heterogeneity in this subset of AML. Here we identify somatic mutations in additional sex combs-lik...

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Hlavní autoři: Micol, Jean-Baptiste, Duployez, Nicolas, Boissel, Nicolas, Petit, Arnaud, Geffroy, Sandrine, Nibourel, Olivier, Lacombe, Catherine, Lapillonne, Helene, Etancelin, Pascaline, Figeac, Martin, Renneville, Aline, Castaigne, Sylvie, Leverger, Guy, Ifrah, Norbert, Dombret, Hervé, Preudhomme, Claude, Abdel-Wahab, Omar, Jourdan, Eric
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2014
Témata:
Clinical Trials and Observations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148766/
https://ncbi.nlm.nih.gov/pubmed/24973361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-571018
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