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Lysosome-oriented, dual-stage pH-responsive polymeric micelles for β-Lapachone delivery
β-Lapachone (β-lap), a novel anticancer agent, is bioactivated by NADP(H):quinone oxidoreductase 1 (NQO1), an enzyme over-expressed in numerous tumors, including lung, pancreas, breast, and prostate cancers. Fast renal clearance and methemaglobinemia / hemolytic side-effects from the clinical formul...
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| Veröffentlicht in: | J Mater Chem B Mater Biol Med |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5452003/ https://ncbi.nlm.nih.gov/pubmed/28580145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C6TB02049F |
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