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Lysosome-oriented, dual-stage pH-responsive polymeric micelles for β-Lapachone delivery
β-Lapachone (β-lap), a novel anticancer agent, is bioactivated by NADP(H):quinone oxidoreductase 1 (NQO1), an enzyme over-expressed in numerous tumors, including lung, pancreas, breast, and prostate cancers. Fast renal clearance and methemaglobinemia / hemolytic side-effects from the clinical formul...
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| Publicat a: | J Mater Chem B Mater Biol Med |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5452003/ https://ncbi.nlm.nih.gov/pubmed/28580145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C6TB02049F |
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